ART BMC Plus

Our products are only available for sale to licensed medical professionals. You need to be registered with Celling Biosciences in order to make purchases.

Login

Description

What is the ART BMC Plus?

  • The ART BMC Plus system processes autologous bone marrow concentrate effectively and efficiently at point-of-care.
  • The system recovers the greatest percentage of nucleated and progenitor cells
  •  The ART BMC Plus features integrated fibers for plasma concentration with minimal sterile breaks to create a fluid rich containing proteins such as VEGF, PDG-F, TGF-β, FGF, Alpha-2 Macroglobulin, Interleukin-1 receptor antagonist protein, and fibrinogen
  • Functionally closed system to minimize sterile breaks
  • Thumbwheel allows for selective deconstruction of fluid stack for personalized fluid products
  • Efficient concentration yields ultra-low hematocrit with only 1 spin
  • 15-20 minute processing time
  • Consistently achieves high yields of platelets and mononuclear cells
  • GFC = Growth Factor Concentrate = Concentrated Plasma
  • GFC Clot = Fibrin Glue with Proteins & Growth Factors!

Included:

  • (1) ART BMC Plus Disposable
  • (1) Clot Filter
  • (3) 35mL Syringes
  • (1) 30mL Vaclok
  • (2) F-F luer connectors
  • (2) syringe caps

Features

  • Fully integrated device to minimize sterile breaks
  • Disposable
  • Thumbwheel allows for variable processing volume
  • Only BMC device on the market with integrated fibers

Benefits

  • High progenitor cell recovery (avg 90 %)1
  • High platelet recovery (avg 71 %)1
  • Eliminates turbulence by keeping buffy coat in the collection zone
  • Ultrafiltration of plasma to obtain essential proteins & growth factors (3x total protein concentration)2

What Proteins, Growth Factors, and Molecules are Present in GFC?2

  • VEGF5
    • New blood vessel growth
    • Endothelial cell migration and proliferation
  • PDGF5
    • New blood vessel growth
    • MSC recruitment and proliferation
    • Helps form bone
    • Increases collagen synthesis
  • TGF-Beta5
    • MSC proliferation
    • Bone matrix deposition
  • FGF5
    • MSC proliferation
    • Wound healing
  • Alpha 2-Macroglobulin (A2M)6
    • Prevents cartilage degeneration
  • IRAP3
    • Interleukin-1 receptor antagonist protein
    • High levels in bone marrow
    • Decreases inflammation
  • FIBRINOGEN5
    • Critcal for clot formation
Cell Type Bone marrow concentrate and growth factor
Cell Source BMA
Cell Content / Recovery 90% progenitor cells (CD34+, CFU-F); 71% platelets1
Protein Concentrate Yes
FDA Status Class I – Exempt

1 Karli et al. Autologous Regenerative Therapies: Rapid Concentration of Progenitor Cells, Platelets, and Proteins at the Point-of-Care” TERMIS Annual Meeting. (2015) Boston, MA

2 Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.

3 Cassano, Jennifer M., et al. “Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration.” Knee Surgery, Sports Traumatology, Arthroscopy (2016): 1-10.

4 Monteforte et al. “Autologous Protein Scaffold Isolated from Platelet Poor Plasma in Bone Marrow Concentrate” World Stem Cell Summit. (2016) West Palm Beach, FL.

5 Barrientos, Stephan, et al. “Growth factors and cytokines in wound healing.” Wound Repair and Regeneration 16.5 (2008): 585-601.

6 Wang, Shaowei, et al. “Identification of α2‐Macroglobulin as a Master Inhibitor of Cartilage‐Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis.” Arthritis & rheumatology 66.7 (2014): 1843-1853

Additional information

revision

F

gtin-14

00817771027606

case-quantity

6

Social Links

©2024 Celling Biosciences, Inc.

Site built by Two Row Studio

Log in with your credentials

Forgot your details?